Corn Cob Bedding! | BackYard Chickens

We recently discovered that housing adult male or female rats on ground corncob bedding blocks male and female sexual behavior and cyclicity (). These results suggested that this bedding material contained endocrine-disruptive substances. We initially postulated that the endocrine-disruptive agent(s) in corncob was likely a phytoestrogen because earlier studies demonstrated that plant isoflavonoids possess estrogenic activity in a variety of experimental systems (; ; ; ). On the basis of these observations, we reasoned that the MCF-7 human breast cancer cell proliferation (the E-Screen) assay () would be a suitable rapid in vitro screen for the endocrine disruptors in extracts of ground corncob bedding. Our initial studies on ground corncob bedding extracts led to the purification of two peaks of mitogenic activity on reverse-phase high-performance liquid chromatography (HPLC). Peak I was purified to homogeneity and identified as an isomeric mixture of 9,12-oxy-10,13-dihydroxyocta-decanoic acid and 10,13-oxy-9,12-dihydroxy-octadecanoic acid [tetrahydrofurandiols (THF-diols)] (). The compounds () were synthesized and found to stimulate MCF-7 human breast cancer proliferation in vitro and block sexual behavior in male rats () and female rats and ovarian cyclicity (; ) at concentrations approximately 200-fold lower than classical phytoestrogens (). In addition, the THF-diols are apparently devoid of estrogenic activity and do not bind to the estrogen receptor (ER) or nuclear type II [3H]estradiol binding sites (, ). Thus, the THF-diols were identified as very active endocrine-disruptive agents that block steroid-hormone–dependent pathways through a nonconventional mechanism.

Many laboratories use corn cob based bedding, as do many bird and reptile enthusiasts.


Corn cob bedding has been shown in several studies to control ammonia in micro-isolation caging better than wood and some recycled paper bedding materials

[IMG] So I got some corn cob bedding instead

Lab Supply offers corn cob bedding from The Andersons and Shepherd Specialty Papers. The goal of this study was to evaluate the effectiveness of a new proprietary processed corncob bedding material (PCC) compared with standard corncob in ventilated and static mouse housing systems. Intracage ammonia levels, bacterial growth, and absorptive capacity of bedding were measured for cages of C57BL/6 mice under nonautoclaved and autoclaved conditions on static and ventilated racks in a barrier facility. Ammonia concentration was measured daily, and cages were removed from the study when measurements reached or exceeded 25 ppm. Bacterial growth in bedding was quantified and speciated before exposure to mice and at the time of cage removal. The absorptive capacity of all bedding material was determined under autoclaved and nonautoclaved conditions. Ventilated cages with PCC or autoclaved corncob took longer to reach ammonia concentrations of 25 ppm than did those with corncob or autoclaved PCC; PCC-filled cages remained below 25 ppm NH3 for at least 3 wk. The type of bedding material did not affect the number of days required to reach 25 ppm in static cages. Compared with other bedding types in the absence of mice, 1/4-in. PCC had a lower and 1/8-in. corncob a higher bacterial load. Autoclaving altered the absorptive capacity of 1/4-in. bedding materials, and for 1/8-in. bedding, corncob was more absorptive than PCC regardless of autoclaving. The results of this study indicate that PCC is comparable to autoclaved corncob in controlling intracage ammonia levels, and a cage-change interval of 3 wk is possible when ventilated cages are used with this bedding.

corn cob bedding review - YouTube

The Guide states that rodents should be housed with bedding because it allows foraging, burrowing, digging, and nest building and absorbs urine and feces. Moreover, the type of bedding selected can influence animal wellbeing and experimental results.,,, Several bedding materials are available for rodents, including corncob, wood chips, paper products, and grass fiber pellets. Bedding is evaluated for absorbency, biodegradability, toxicity, dust, palatability, comfort, cost, availability, damage to cage washers, and effect on research., Untreated softwood bedding can affect rodent metabolism,, and the aromatic hydrocarbons of cedar shavings can induce hepatic microsomal enzymes and cytotoxicity., Aspen bedding is associated with sneezing and respiratory pathology in rats. In a study comparing aspen shavings, virgin pulp, recycled paper, corncob, reclaimed wood pulp, virgin cellulose, pine shavings, and hardwood chips, ammonia was detectable last in corncob. Rats have been shown to prefer paper bedding to corncob; however, corncob has been used to minimize dampness and ammonia concentrations. Mice prefer material suitable for nest building such as cloth, cotton, or paper.,,, Although corncob bedding is not a sterile material,,, it is a common bedding choice due to its absorbency, biodegradability, and ability to control ammonia levels. In this study, corncob bedding was used as the control for comparison with a new processed corncob bedding material and because it is the most common bedding material used in our facilities.

Update! Ground corn cob bedding - Chronicle Forums